Description

Megestrol Acetate CAS NO 595-33-5 is a synthetic, steroidal progestin widely recognized for its potent hormonal activity. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced therapeutic formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of oncology and endocrine disorder treatments.

Application

• Pharmaceutical API: Core active ingredient in the formulation of oral tablets and suspensions for the treatment of hormone-sensitive cancers, such as breast and endometrial cancer.
• Appetite Stimulation Therapy: Used in specialized formulations to manage cachexia and severe weight loss in patients with AIDS or cancer.
• Hormone Replacement Therapy (HRT): A key component in certain HRT regimens for managing menopausal symptoms and hormonal imbalances.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for estrus suppression and the management of reproductive disorders in animals.
• Biomedical Research: Serves as a critical reference standard and tool compound in pharmacological studies, receptor binding assays, and metabolic research.
• Contraceptive Formulations: Historically and in specific combination therapies, used for its progestogenic effects.

Basic Information

Product Name	Megestrol Acetate
CAS No.	595-33-5
Molecular Formula	C24H32O4
Molecular Weight	384.51 g/mol
Synonyms	Megestrol Acetate; 17α-Acetoxy-6-methylpregna-4,6-diene-3,20-dione; BDH 1293; Maygace; Megace; Niagestin; Ovaban; SC-10363; 6-Methyl-6-dehydro-17α-acetoxyprogesterone
EINECS	209-864-5

Quality Control

Our Megestrol Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmacopeial standards, including identification, assay, and impurity profile checks. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.