Description

4-Trifluoromethylthio-Benzoic Acid Ethyl Ester is a high-value fluorinated aromatic building block characterized by its trifluoromethylthio (-SCF₃) and ethyl ester functional groups. This compound is essential for introducing lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the -SCF₃ group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a substrate for further functionalization to create complex, fluorinated molecular architectures.

Basic Information

Product Name	4-Trifluoromethylthio-Benzoic Acid Ethyl Ester
CAS No.	587-19-9
Molecular Formula	C₁₀H₉F₃O₂S
Molecular Weight	250.24 g/mol
Synonyms	Ethyl 4-(Trifluoromethylthio)benzoate; Benzoic acid, 4-[(trifluoromethyl)thio]-, ethyl ester; p-(Trifluoromethylthio)benzoic acid ethyl ester; 4-(Trifluoromethylsulfanyl)benzoic acid ethyl ester; Ethyl p-trifluoromethylthiobenzoate; NSC 404083; 587-19-9
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylthio-Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.