Description

1,3,5(10)-Estratrien-3,15-Alpha, 17-β-Triol is a high-purity steroidal compound, also known as Estriol, serving as a critical intermediate and reference standard in advanced pharmaceutical synthesis. Its precise chemical structure is essential for research and development in hormone-related therapies and diagnostic applications. This compound is primarily required by manufacturers and R&D facilities in the pharmaceutical, biotechnology, and fine chemical sectors for producing active pharmaceutical ingredients (APIs) and analytical standards.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of steroidal drugs and hormone replacement therapies.
• Analytical Reference Standard: Used for quality control, method validation, and calibration in HPLC, GC, and other chromatographic analyses.
• Biochemical Research: Employed in studies of estrogen receptor binding, metabolic pathways, and endocrinology.
• API Manufacturing: Serves as a precursor in the production of estriol-based active pharmaceutical ingredients.
• Diagnostic Reagents: Utilized in the development of immunoassays and diagnostic kits for hormonal level detection.

Basic Information

Product Name	1,3,5(10)-Estratrien-3,15-Alpha, 17-β-Triol
CAS No.	570-30-9
Molecular Formula	C18H24O3
Molecular Weight	288.38 g/mol
Synonyms	Estriol; Oestriol; 16,17-Dihydroxyestra-1,3,5(10)-trien-3-ol; Theelol; Trihydroxyestrin; E3; NSC 12173; 1,3,5-Estratriene-3,15α,17β-triol
EINECS	209-318-1

Quality Control

Our 1,3,5(10)-Estratrien-3,15-Alpha, 17-β-Triol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity determination by HPLC, and specific tests for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.