Description

1,3,5[10]-Estratriene-3,16Alpha-Diol-17-One is a high-purity steroid intermediate, also known as 16α-Hydroxyestrone, with the CAS registry number 566-76-7. This compound is a critical building block in the synthesis of complex steroid hormones and pharmaceutical active ingredients, valued for its defined stereochemistry and purity. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical synthesis facilities focused on endocrinology, oncology, and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of estrane-based steroid drugs and hormone therapies.
• Biochemical Research: Used as a reference standard and reagent in metabolic pathway studies and endocrine research.
• Fine Chemical Synthesis: Serves as a chiral starting material for the production of more complex, biologically active steroid derivatives.
• Analytical Standard: Employed in analytical methods development and validation for quality control in pharmaceutical manufacturing.

Basic Information

Product Name	1,3,5[10]-Estratriene-3,16Alpha-Diol-17-One
CAS No.	566-76-7
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	16α-Hydroxyestrone; 16α-Hydroxy-1,3,5(10)-estratriene-3,17-dione; 3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one; Estr-1,3,5(10)-triene-3,16α-diol-17-one; 16α-Hydroxy-Estrone; 16α-Hydroxyoestrone; 16α-OH-Estrone
EINECS	209-294-5

Quality Control

Our 1,3,5[10]-Estratriene-3,16Alpha-Diol-17-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.