Description

Probarbital is a synthetic barbiturate derivative, a class of compounds historically significant for their central nervous system depressant properties. Its precise chemical structure makes it a valuable reference standard and a key intermediate in pharmaceutical research and development. This compound is primarily utilized by research institutions, analytical laboratories, and fine chemical manufacturers focused on neuropharmacology, forensic analysis, and the synthesis of specialized pharmaceutical agents.

Application

• Pharmaceutical Reference Standard: Used for qualitative and quantitative analysis in method development and validation for regulatory compliance.
• Biochemical Research: Serves as a tool compound in neuroscience studies investigating GABAA receptor modulation and sedative-hypnotic mechanisms.
• Forensic Toxicology: Employed as a calibrant or control in the detection and quantification of barbiturates in biological samples.
• Chemical Synthesis: Acts as a crucial building block or intermediate in the preparation of more complex barbiturate analogs and related heterocyclic compounds.
• Quality Control: Used by manufacturers to verify the identity and purity of related active pharmaceutical ingredients (APIs) or finished drug products.

Basic Information

Product Name	Probarbital
CAS No.	545-74-4
Molecular Formula	C9H14N2O3
Molecular Weight	198.22 g/mol
Synonyms	5-Ethyl-5-propyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-propylbarbituric Acid; Ethylpropylmalonylurea; NSC 3069; Probarbital Sodium (salt form); Propallylonal (related compound); Allylpropymal; Ethylpropylbarbituric Acid
EINECS	208-889-7

Quality Control

Our Probarbital is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods, purity assay, and control of related substances and residual solvents, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.