Description

Proguanil Hydrochloride is a synthetic biguanide derivative widely recognized for its potent antimalarial properties. Its primary value lies in its role as a key pharmaceutical active ingredient, particularly for the prophylaxis and treatment of malaria, often in synergistic combination therapies. This compound is essential for manufacturers in the pharmaceutical industry, specifically those producing antimalarial drugs, as well as for research institutions engaged in parasitology and infectious disease studies. Its reliable quality and consistent supply are critical for global health initiatives targeting malaria-endemic regions.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in antimalarial medications for both prevention (prophylaxis) and treatment.
• Fixed-Dose Combination Therapies: Used in combination with atovaquone (e.g., Malarone®) for enhanced efficacy against Plasmodium falciparum malaria.
• Research & Development: Serves as a critical reference standard and intermediate in pharmacological and parasitological research for novel antimalarial agents.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for the prevention of protozoal infections in animals.
• Chemical Synthesis: Acts as a key intermediate or starting material for the synthesis of more complex biguanide derivatives and related compounds.

Basic Information

Product Name	Proguanil Hydrochloride
CAS No.	537-21-3
Molecular Formula	C11H16ClN5•HCl
Molecular Weight	290.19 g/mol
Synonyms	Chloroguanide Hydrochloride; Proguanil HCl; 1-(4-Chlorophenyl)-5-isopropylbiguanide Hydrochloride; Paludrine; Bigumal; Drinupal; Tirian; Chloroguanide Monohydrochloride; ICI 33828
EINECS	208-653-8

Quality Control

Our Proguanil Hydrochloride is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. We provide material that complies with major pharmacopoeial specifications, including USP and EP monographs. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request to ensure full traceability and regulatory compliance for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Chloride)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.