Description

o-Desmethyl Quinine CAS NO 524-63-0 is a key intermediate and metabolite of the antimalarial drug quinine. This compound is of significant interest in pharmaceutical research and development, particularly for metabolic studies and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, analytical method development, and pharmacokinetic profiling.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification and quantification of quinine metabolites in biological matrices during clinical and preclinical studies.
• Metabolic Pathway Research: Used as a critical tool in pharmacological research to study the biotransformation and clearance pathways of quinine and related alkaloids.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a high-purity building block in the synthetic pathways for developing new antimalarial and other therapeutic compounds.
• Analytical Chemistry: Employed in the development and validation of analytical methods, such as HPLC and LC-MS/MS, for drug impurity profiling and bioanalysis.
• Biochemical Research: Utilized in in-vitro studies to investigate drug-receptor interactions and the biochemical mechanisms of action for cinchona alkaloid derivatives.

Basic Information

Product Name	o-Desmethyl Quinine
CAS No.	524-63-0
Molecular Formula	C₁₉H₂₂N₂O₂
Molecular Weight	310.39 g/mol
Synonyms	10,11-Dihydro-10-hydroxyquinine; 10-Hydroxydihydroquinine; (8S,9R)-10,11-Dihydro-10-hydroxy-6'-methoxycinchonan-9-ol; 10-Hydroxyquinine; Quinine, 10,11-dihydro-10-hydroxy-; 10-Hydroxydihydroquinine; 10-Hydroxy-10,11-dihydroquinine; NSC 329699
EINECS	Contact for details

Quality Control

Our o-Desmethyl Quinine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.