Description

(8α)-Estradiol CAS NO 517-04-4 is a stereoisomer of the endogenous estrogen hormone estradiol, distinguished by its specific configuration at the 8-position. This compound is of significant interest in pharmaceutical research and development, particularly for studying structure-activity relationships and receptor binding profiles of estrogenic compounds. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in the production of steroidal APIs and finished dosage forms.
• Biochemical Research: A key tool for investigating estrogen receptor (ER) subtype selectivity, metabolic pathways, and the biological effects of specific estradiol isomers.
• Intermediate for Synthesis: Serves as a chiral building block or precursor in the synthesis of novel steroidal compounds and potential therapeutic agents.
• Academic & Contract Research: Essential for university laboratories and CROs conducting fundamental endocrinology, pharmacology, and toxicology studies.
• Diagnostic Development: May be utilized in the development and calibration of immunoassays and other diagnostic kits for hormone level detection.

Basic Information

Product Name	(8α)-Estradiol
CAS No.	517-04-4
Molecular Formula	C18H24O2
Molecular Weight	272.38 g/mol
Synonyms	8α-Estradiol; 8-Epiestradiol; 8α-Estra-1,3,5(10)-triene-3,17β-diol; 8α-Oestradiol; Estra-1,3,5(10)-triene-3,17β-diol (8α); 8α-Hydroxyestradiol; NSC 9894
EINECS	208-228-5

Quality Control

Our (8α)-Estradiol is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.