Description

Cycloguanil CAS NO 516-21-2 is a synthetic biguanide derivative and the primary active metabolite of the antimalarial drug proguanil. This compound is critical for research and development in the pharmaceutical industry, particularly in the study of antimalarial mechanisms and resistance. It serves as a key intermediate and reference standard for manufacturers and research institutions focused on infectious disease therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of advanced antimalarial drug candidates and related therapeutic agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of proguanil and its formulations.
• Biochemical Research: Employed in studies investigating the mechanism of action against Plasmodium species, specifically targeting dihydrofolate reductase (DHFR).
• Metabolite Studies: Essential for pharmacokinetic and metabolic profiling research to understand the biotransformation of proguanil in biological systems.
• Antiparasitic Agent Development: Investigated for potential efficacy against other protozoan parasites beyond malaria, contributing to new drug discovery pipelines.

Basic Information

Product Name	Cycloguanil
CAS No.	516-21-2
Molecular Formula	C11H15ClN6
Molecular Weight	266.73 g/mol
Synonyms	1-(4-Chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine; Chloroguanide triazine; Cycloguanil pamoate (salt form); WR 38839; NSC 32968; CI 501; Chlorproguanil metabolite; Triazinediamine derivative
EINECS	208-225-8

Quality Control

Our Cycloguanil is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other validated methods, to ensure it meets high-purity standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.