Description

Belladonna Total Alkaloids is a standardized extract derived from the *Atropa belladonna* plant, primarily consisting of the tropane alkaloids atropine, hyoscyamine, and scopolamine. This complex mixture is valued for its consistent pharmacological activity, which is critical for ensuring predictable therapeutic outcomes in formulated products. It serves as a key active pharmaceutical ingredient (API) and intermediate for manufacturers in the pharmaceutical, research, and botanical extract industries, where precise control over alkaloid content is paramount.

Application

• Pharmaceutical Manufacturing: As a bulk active pharmaceutical ingredient (API) in the formulation of antispasmodic and anticholinergic medications.
• Research & Development: Used as a reference standard and biochemical tool in pharmacological studies targeting the muscarinic acetylcholine receptor system.
• Botanical Extracts: Serves as a standardized botanical extract for use in regulated herbal preparations where consistent potency is required.
• Analytical Standards: Employed as a calibrant and control material in quality control laboratories for the assay of belladonna-based products.
• Veterinary Pharmaceuticals: Utilized in the production of veterinary drugs for its antispasmodic and antisecretory effects.

Basic Information

Product Name	Belladonna Total Alkaloids
CAS No.	510-25-8
Molecular Formula	Complex Mixture (C17H23NO3, C17H21NO4, etc.)
Molecular Weight	Varies by Alkaloid (e.g., Atropine: 289.38 g/mol)
Synonyms	Belladonna Alkaloids; Deadly Nightshade Alkaloids; Atropa Belladonna Alkaloids; Total Belladonna Alkaloids; Tropic Acid Esters; Bellafoline (historical); Belladonnine (impurity); Atropine Group Alkaloids
EINECS	208-088-7

Quality Control

Our Belladonna Total Alkaloids are produced and tested under a strict quality management system to ensure batch-to-batch consistency and compliance with relevant pharmacopoeial standards. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing the alkaloid profile, purity, and identification. We can supply material aligned with various monograph requirements, including USP and EP specifications for related substances and assay.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference
Assay (Total Alkaloids)	≥ 95.0% (as calculated)
Specific Rotation	-20° to -23° (c=2 in H2O)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.