Description

Pyrimethamine is a synthetic diaminopyrimidine derivative that functions as a potent and selective inhibitor of dihydrofolate reductase (DHFR). This mechanism of action makes it a critical active pharmaceutical ingredient (API) for the treatment and prevention of specific parasitic infections. It is essential for manufacturers in the pharmaceutical industry, particularly for producing antimalarial and antiprotozoal medications. Our supply of Pyrimethamine CAS NO 58-14-0 is characterized by high purity and reliable consistency to meet stringent formulation requirements.

Application

• Antimalarial Drug Production: Primary use as a key API in fixed-dose combination therapies, often paired with sulfadoxine, for the treatment and prophylaxis of malaria caused by Plasmodium falciparum.
• Toxoplasmosis Treatment: Critical component in combination therapy (typically with sulfadiazine) for treating toxoplasmosis, especially in immunocompromised patients and for congenital infection.
• Veterinary Pharmaceuticals: Used in veterinary medicine for the prevention and treatment of protozoal infections, such as coccidiosis and other parasitic diseases in livestock and companion animals.
• Research & Development: Serves as a reference standard and a biochemical tool in pharmacological and parasitological research to study DHFR inhibition and drug resistance mechanisms.
• Pharmaceutical Intermediates: Acts as a chemical building block for the synthesis of more complex therapeutic agents and analogs in medicinal chemistry.

Basic Information

Product Name	Pyrimethamine
CAS No.	58-14-0
Molecular Formula	C12H13ClN4
Molecular Weight	248.71 g/mol
Synonyms	2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; Daraprim; Chloridin; Malocide; Tindurin; Pirimecidan; Pyrimethaminum; WR-4873
EINECS	200-364-9

Quality Control

Our Pyrimethamine is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via validated methods such as HPLC. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with in-house specifications that align with major pharmacopoeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.