Description

Estradiol CAS NO 57-91-0 is the primary and most potent naturally occurring estrogen steroid hormone. It is a critical active pharmaceutical ingredient (API) and a fundamental biochemical standard for research and development. This compound is essential for manufacturers and researchers in the pharmaceutical, biotechnology, and life sciences sectors, where precise hormonal activity and high purity are paramount for product efficacy and experimental validity.

Application

• Pharmaceutical API: Core active ingredient in hormone replacement therapy (HRT) medications, transdermal patches, and topical creams for managing menopausal symptoms and hormonal deficiencies.
• Veterinary Medicine: Used in formulations for estrus synchronization and fertility treatments in livestock and companion animals.
• Biochemical Research: Serves as a key reference standard and reagent in endocrinology, oncology, and developmental biology studies to investigate estrogen receptor signaling.
• In Vitro Diagnostics: Critical component in the calibration of immunoassay kits and systems for clinical hormone level testing.
• Cosmeceutical R&D: Employed in research for developing advanced skincare products targeting age-related skin changes, though final formulations typically use derivatives.

Basic Information

Product Name	Estradiol
CAS No.	57-91-0
Molecular Formula	C18H24O2
Molecular Weight	272.38 g/mol
Synonyms	17β-Estradiol; E2; Dihydrofolliculin; Dihydrotheelin; 3,17β-Dihydroxy-1,3,5(10)-estratriene; 1,3,5(10)-Estratriene-3,17β-diol; Estra-1,3,5(10)-triene-3,17β-diol; Oestradiol
EINECS	200-353-9

Quality Control

Our Estradiol is manufactured under strict quality management systems. It is available in various grades, including high-purity pharmaceutical standards suitable for API use. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure identity, potency, and purity. Certificates of Analysis (COA) documenting compliance with relevant specifications are provided and can be tailored to meet specific pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, prolonged exposure to light and air should be avoided. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+76° to +83° (c = 1 in dioxane)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.