Description

Nalorphine Hydrochloride is a potent opioid antagonist and partial agonist, primarily recognized for its role in pharmacological research and development. This compound is crucial for studying opioid receptor mechanisms, developing new analgesic therapies, and investigating treatments for substance abuse disorders. It serves as an essential reference standard and active pharmaceutical ingredient (API) for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors.

Application

• Pharmacological Research: Used as a key reference compound in studies of opioid receptor binding, antagonism, and partial agonist activity.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in HPLC, GC-MS, and other analytical techniques.
• Drug Development: Employed in the research and preclinical development of new analgesic drugs and opioid overdose reversal agents.
• Neuroscience Studies: Utilized in experimental models to understand pain pathways, addiction mechanisms, and neuropharmacology.
• Pharmaceutical Manufacturing: Can be incorporated as an active pharmaceutical ingredient (API) in specialized formulations for clinical research purposes.
• Forensic & Clinical Toxicology: Acts as a calibration standard in laboratories for the detection and quantification of opioids in biological samples.

Basic Information

Product Name	Nalorphine Hydrochloride
CAS No.	57-29-4
Molecular Formula	C19H21NO3·HCl
Molecular Weight	347.84 g/mol
Synonyms	N-Allylnormorphine Hydrochloride; N-Allylnorcodeinone Hydrochloride; Lethidrone Hydrochloride; Nalorphine HCl; NANM Hydrochloride; (-)-N-Allyl-7,8-didehydro-4,5α-epoxy-17-methylmorphinan-3,6α-diol Hydrochloride; 17-Allyl-7,8-didehydro-4,5α-epoxymorphinan-3,6α-diol Hydrochloride
EINECS	200-311-5

Quality Control

Our Nalorphine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.