Description

Methantheline Bromide CAS NO 53-46-3 is a quaternary ammonium anticholinergic agent. This compound is significant for its potent antimuscarinic and ganglionic blocking properties, making it a valuable intermediate in pharmaceutical research and development. It is primarily needed by manufacturers in the pharmaceutical industry for the synthesis of specialized therapeutic agents targeting gastrointestinal and urinary tract spasms.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of antispasmodic and antisecretory drugs.
• Research & Development: Used in pharmacological studies to investigate cholinergic receptor mechanisms and develop new therapeutic agents.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the controlled production of finished dosage forms for treating peptic ulcers and related conditions.

Basic Information

Product Name	Methantheline Bromide
CAS No.	53-46-3
Molecular Formula	C₂₁H₂₆BrNO₃
Molecular Weight	420.34 g/mol
Synonyms	Banthine Bromide; Methanthelinium Bromide; Diethyl(2-hydroxyethyl)methylammonium Bromide Xanthene-9-carboxylate; N-Methyl-N-(2-hydroxyethyl)-N,N-diethylammonium Bromide 9-Xanthenecarboxylate; 9H-Xanthene-9-carboxylic acid, compd. with (2-hydroxyethyl)diethylmethylammonium bromide (1:1); Avagal; Vagamin; Xanthenol.
EINECS	200-179-5

Quality Control

Our Methantheline Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.