Description

Estrone CAS NO 53-16-7 is a naturally occurring estrogen steroid hormone and a primary metabolite of estradiol. It is a critical intermediate and reference standard in the research and development of hormonal therapies and diagnostic agents. This compound is essential for pharmaceutical manufacturers, academic research institutions, and biotechnology companies focused on endocrinology, oncology, and women's health.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of various steroidal drugs and hormone replacement therapies (HRT).
• Reference Standard: Used as a high-purity standard in analytical laboratories for quality control (QC) and research and development (R&D) to calibrate equipment and validate methods (e.g., HPLC, GC-MS).
• Biochemical Research: Employed in studies investigating estrogen receptor (ER) binding, hormone metabolism, and the pathophysiology of estrogen-related conditions.
• Diagnostic Reagents: Serves as a critical component in the development and manufacture of immunoassay kits for measuring estrogen levels in clinical and research settings.
• Veterinary Medicine: Used in formulations for animal health, particularly in reproductive management.

Basic Information

Product Name	Estrone
CAS No.	53-16-7
Molecular Formula	C18H22O2
Molecular Weight	270.37 g/mol
Synonyms	Estrone; 1,3,5(10)-Estratrien-3-ol-17-one; 3-Hydroxyestra-1,3,5(10)-trien-17-one; Estra-1,3,5(10)-trien-3-ol-17-one; Folliculin; Ketohydroxyestrin; Oestrone; Theelin
EINECS	200-164-5

Quality Control

Our Estrone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and specific tests for related substances, to ensure it meets high-purity standards suitable for pharmaceutical and research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Specific Rotation	+158° to +168° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.