Description

Chlormethine CAS NO 51-75-2 is a nitrogen mustard alkylating agent with significant historical and clinical importance. This compound is a critical active pharmaceutical ingredient (API) used in the formulation of specific chemotherapeutic agents. It is primarily required by pharmaceutical manufacturers and advanced research institutions focused on oncology. Its role underscores the need for a highly reliable and quality-assured supply chain for critical medical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of mechlorethamine hydrochloride, a chemotherapeutic agent.
• Oncology Treatment: Used in the treatment of certain lymphomas, including Hodgkin's lymphoma and cutaneous T-cell lymphoma (mycosis fungoides).
• Topical Chemotherapy: Application in topical solutions or gels for the treatment of skin manifestations of lymphoma.
• Biomedical Research: Utilized as a model alkylating agent in biochemical and pharmacological studies of DNA interaction and cytotoxicity mechanisms.
• Chemical Intermediate: Serves as a key synthetic intermediate in the research and development of other nitrogen mustard derivatives and related compounds.

Basic Information

Product Name	Chlormethine
CAS No.	51-75-2
Molecular Formula	C5H11Cl2N
Molecular Weight	156.05 g/mol
Synonyms	Mechlorethamine; Mustine; HN2; Nitrogen Mustard; Bis(2-chloroethyl)methylamine; 2-Chloro-N-(2-chloroethyl)-N-methylethanamine; Chlorethazine; Embichin
EINECS	200-120-5

Quality Control

Our Chlormethine is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via validated methods such as HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable safety regulations for cytotoxic substances.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.