Description

Scopolaminemethylnitrate CAS NO 51-33-2 is a quaternary ammonium derivative of the tropane alkaloid scopolamine, known for its potent anticholinergic and antimuscarinic properties. This compound is a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of specialized pharmaceuticals. It is primarily required by manufacturers in the pharmaceutical, research, and fine chemical sectors for the development of therapeutic agents targeting motion sickness, gastrointestinal disorders, and as a pre-anesthetic medication.

Application

• Pharmaceutical API: Core active ingredient in the formulation of antiemetic and antispasmodic injectable solutions and transdermal patches.
• Motion Sickness Prevention: Used in the production of prophylactic medications for nausea and vomiting associated with travel and sea sickness.
• Pre-anesthetic Medication: Employed to reduce salivary and bronchial secretions before surgery.
• Gastrointestinal Therapeutics: Key component in drugs for treating irritable bowel syndrome (IBS) and other smooth muscle spasms.
• Ophthalmic Solutions: Used in diagnostic procedures to induce cycloplegia (paralysis of the ciliary muscle) and mydriasis (pupil dilation).
• Biochemical Research: Serves as a standard and tool compound in neurological and pharmacological studies of cholinergic receptors.
• Veterinary Medicine: Applied in formulations for animal health, particularly for sedation and as an anti-sialagogue.

Basic Information

Product Name	Scopolaminemethylnitrate
CAS No.	51-33-2
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	Hyoscine Methonitrate; Scopolamine Methonitrate; Methscopolamine Nitrate; Pamine Nitrate; (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate methyl nitrate; Scopolamine Methyl Nitrate; Hyoscine Methylnitrate; Epoxytropine Tropate Methyl Nitrate
EINECS	200-074-1

Quality Control

Our Scopolaminemethylnitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards, including identity confirmation, assay, and control of specific impurities. Certificates of Analysis (COA) documenting compliance with relevant specifications, including in-process Ph. Eur. / USP monographs where applicable, are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.