Description

β-Estradiol CAS NO 50-28-2 is the primary and most potent naturally occurring estrogen steroid hormone. It is a critical active pharmaceutical ingredient (API) and a fundamental reference standard in research and development. This compound is essential for manufacturers and researchers in the pharmaceutical, biotechnology, and life science sectors, where precise hormonal activity and high purity are paramount for product efficacy and experimental validity.

Application

• Pharmaceutical API: Core ingredient in hormone replacement therapy (HRT) medications, transdermal patches, and other formulations for treating menopausal symptoms, osteoporosis, and certain hormone-sensitive conditions.
• Research & Development: Vital reference standard and biochemical tool in endocrinology, oncology, and reproductive biology studies to understand estrogen receptor signaling and cellular mechanisms.
• In-vitro Diagnostics (IVD): Used in the calibration and development of immunoassay kits and other diagnostic tests for measuring estrogen levels in clinical and research settings.
• Veterinary Medicine: Employed in therapeutic applications for animals, particularly in reproductive health management.
• Cell Culture & Biotechnology: A key component in specialized cell culture media to study hormone-dependent cell growth and differentiation.

Basic Information

Product Name	β-Estradiol
CAS No.	50-28-2
Molecular Formula	C18H24O2
Molecular Weight	272.38 g/mol
Synonyms	17β-Estradiol; Estradiol; E2; Dihydrofolliculin; Dihydrotheelin; Oestradiol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; 1,3,5(10)-Estratriene-3,17β-diol
EINECS	200-023-8

Quality Control

Our β-Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and melting point, and residual solvent analysis to ensure it meets stringent specifications. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and compliance with relevant pharmacopeial standards (e.g., USP, EP) for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Melting Point	173°C - 179°C
Assay (HPLC)	≥ 98.0%
Specific Rotation	+76° to +83°
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.