Description

1-Methyl-1H-Imidazol-5-Yl Isocyanate is a specialized heterocyclic isocyanate building block of significant interest in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 1-methylimidazole pharmacophore into target molecules via urea or carbamate linkages. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing small molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with specific modes of action.
• Polymer Modification: Serves as a functional monomer or cross-linking agent to introduce imidazole functionality into polymers for specialty coatings or adhesives.
• Chemical Biology Probes: Utilized in the development of activity-based probes and bioconjugation reagents for proteomics and diagnostic research.
• Ligand Synthesis: Precursor for creating complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1-Methyl-1H-Imidazol-5-Yl Isocyanate
CAS No.	499770-99-9
Molecular Formula	C5H5N3O
Molecular Weight	123.11 g/mol
Synonyms	5-Isocyanato-1-methyl-1H-imidazole; 1-Methyl-5-isocyanatoimidazole; 1-Methylimidazol-5-yl isocyanate; 1-Methyl-1H-imidazole-5-isocyanate; 5-Isocyanato-1-methylimidazole; Isocyanic acid 1-methyl-1H-imidazol-5-yl ester
EINECS	Contact for details

Quality Control

Every batch of our 1-Methyl-1H-Imidazol-5-Yl Isocyanate is manufactured and tested under strict quality management systems. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.