Description

4-(3-Trimethylsilanylethynyl-Pyridin-2-Yl)-Morpholine is a specialized organosilicon building block featuring a pyridine core functionalized with a trimethylsilyl-protected alkyne and a morpholine group. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex heterocyclic systems. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Material Science: Serves as a precursor for functionalized polymers and advanced organic electronic materials due to its conjugated alkyne moiety.
• Cross-Coupling Reactions: The protected alkyne group makes it an ideal substrate for Sonogashira and other palladium-catalyzed coupling reactions.
• Ligand and Catalyst Development: Used to create novel nitrogen-containing ligands for transition metal catalysis.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in synthetic organic chemistry.

Basic Information

Product Name	4-(3-Trimethylsilanylethynyl-Pyridin-2-Yl)-Morpholine
CAS No.	499193-56-5
Molecular Formula	C14H20N2OSi
Molecular Weight	260.41 g/mol
Synonyms	4-[3-(Trimethylsilyl)ethynyl]pyridin-2-yl]morpholine; 2-Morpholino-4-(3-trimethylsilylethynyl)pyridine; 4-(3-Trimethylsilylethynyl-2-pyridinyl)morpholine; 4-(3-Trimethylsilylethynylpyridin-2-yl)morpholine; 4-(3-Trimethylsilylethynyl-2-pyridyl)morpholine; 4-(3-(Trimethylsilyl)ethynyl)pyridin-2-yl)morpholine; TMS-Ethynyl Morpholino Pyridine; CAS 499193-56-5
EINECS	Contact for details

Quality Control

Our 4-(3-Trimethylsilanylethynyl-Pyridin-2-Yl)-Morpholine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.