Description

3-Trimethylsilanylethynyl-Pyridine-2-Carboxylic Acid Amide is a specialized organosilicon building block featuring a pyridine core functionalized with a trimethylsilylethynyl group and a carboxamide moiety. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and functional materials. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological or oncological pathways.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its pyridine-based structure.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers and silicon-containing hybrid materials.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The ethynyl group makes it a valuable substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new synthetic routes.

Basic Information

Product Name	3-Trimethylsilanylethynyl-Pyridine-2-Carboxylic Acid Amide
CAS No.	499193-54-3
Molecular Formula	C12H16N2OSi
Molecular Weight	232.36 g/mol
Synonyms	3-((Trimethylsilyl)ethynyl)picolinamide; 3-(Trimethylsilylethynyl)-2-pyridinecarboxamide; 3-(Trimethylsilylethynyl)picolinamide; 2-Pyridinecarboxamide, 3-[(trimethylsilyl)ethynyl]-; 3-Ethynyl-2-pyridinecarboxamide, trimethylsilyl derivative; TMS-Ethynyl Picolinamide; CAS 499193-54-3
EINECS	Contact for details

Quality Control

Our 3-Trimethylsilanylethynyl-Pyridine-2-Carboxylic Acid Amide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems support compliance with global regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.