Description

Cenicriviroc CAS NO 497223-25-3 is a potent, orally bioavailable dual antagonist of the chemokine receptors CCR2 and CCR5. This small molecule is of significant interest for its potential to modulate inflammatory and fibrotic pathways. It is primarily utilized in pharmaceutical research and development for investigating treatments for non-alcoholic steatohepatitis (NASH), liver fibrosis, and other inflammatory conditions.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) for clinical research and drug development.
• Key intermediate in the synthesis of advanced CCR2/CCR5 antagonist drug candidates.
• Biochemical tool compound for in vitro and in vivo pharmacological studies targeting chemokine receptors.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Research into therapeutic applications for fibrotic diseases, including renal and pulmonary fibrosis.
• Investigation of potential in immunology and oncology research due to its role in macrophage recruitment.

Basic Information

Product Name	Cenicriviroc
CAS No.	497223-25-3
Molecular Formula	C₂₆H₃₀F₂N₄O₃
Molecular Weight	484.54 g/mol
Synonyms	Cenicriviroc; TAK-652; TAK652; CCR2/CCR5 antagonist TAK-652; 8-[3-(2-Methoxyethoxy)benzyl]-1-[(2-methyl-1H-benzimidazol-1-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; (R)-8-[3-(2-Methoxyethoxy)benzyl]-1-[(2-methyl-1H-benzimidazol-1-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
EINECS	Contact for details

Quality Control

Our Cenicriviroc is manufactured under strict GMP-like conditions suitable for pharmaceutical research. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided, confirming compliance with in-house specifications. We support our clients with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.