Description

2,6-Bis[(4R,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-Pyridine is a high-purity, chiral bis(oxazoline) ligand, a critical component in asymmetric synthesis and catalysis. Its value lies in enabling highly enantioselective transformations, which are essential for producing single-isomer pharmaceuticals and fine chemicals. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel synthetic pathways.

Application

• As a chiral ligand in asymmetric catalysis, including Diels-Alder, cyclopropanation, and aldol reactions.
• For the enantioselective synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• In the development of novel metal-organic frameworks (MOFs) and coordination polymers with specific chiral properties.
• As a key component in asymmetric polymerization catalysts for producing stereoregular polymers.
• For academic and industrial R&D in exploring new catalytic systems and reaction methodologies.
• In the synthesis of agrochemicals requiring specific stereochemistry for enhanced activity and safety.

Basic Information

Product Name	2,6-Bis[(4R,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-Pyridine
CAS No.	497172-36-8
Molecular Formula	C35H27N3O2
Molecular Weight	521.61 g/mol
Synonyms	(R,S)-2,6-Bis(4,5-dihydro-4,5-diphenyl-2-oxazolyl)pyridine; Pyridine, 2,6-bis[(4R,5S)-4,5-dihydro-4,5-diphenyl-2-oxazolyl]-; (4R,5S)-4,5-Dihydro-2-[6-[(4R,5S)-4,5-dihydro-4,5-diphenyl-2-oxazolyl]-2-pyridinyl]-4,5-diphenyloxazole; (R,S)-Bis(4,5-dihydro-4,5-diphenyl-2-oxazolyl)pyridine; Chiral PyBOX Ligand; (R,S)-PyBOX-Ph; 2,6-Bis[(4R,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl]pyridine
EINECS	Contact for details

Quality Control

Our 2,6-Bis[(4R,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-Pyridine is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support compliance with cGMP and ISO standards for research and commercial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.