Description

2-(2,6-Dioxopiperidin-3-Yl)-4-(Hydroxyamino)Isoindoline-1,3-Dione is a high-purity, synthetic small molecule belonging to the class of immunomodulatory imide drugs (IMiDs). This compound is of significant interest for its potent biological activity, particularly in targeted protein degradation research and pharmaceutical development. It serves as a critical building block and reference standard for researchers and manufacturers in the life sciences sector.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel targeted therapeutics and proteolysis-targeting chimeras (PROTACs).
• Biochemical Research: Used as a reference standard and active compound in studies involving immunomodulation, anti-angiogenesis, and anti-inflammatory pathways.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and structure-activity relationship (SAR) studies for oncology and autoimmune disease targets.
• Academic Research: Utilized in university and institutional labs for investigating cereblon (CRBN)-dependent protein degradation mechanisms.
• Standards & Calibration: Serves as a certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	2-(2,6-Dioxopiperidin-3-Yl)-4-(Hydroxyamino)Isoindoline-1,3-Dione
CAS No.	497147-11-2
Molecular Formula	C₁₃H₁₂N₄O₅
Molecular Weight	304.26 g/mol
Synonyms	4-Hydroxyamino-lenalidomide; 4-NHOH-Lenalidomide; 4-Hydroxyamino-Revlimid analog; 2-(2,6-Dioxo-3-piperidinyl)-4-(hydroxyamino)-1H-isoindole-1,3(2H)-dione; 4-Hydroxylamino-lenalidomide; 4-HA-Lenalidomide; 4-N-hydroxyamino-lenalidomide; 4-Hydroxyamino derivative of lenalidomide
EINECS	Contact for details

Quality Control

Every batch of our 2-(2,6-Dioxopiperidin-3-Yl)-4-(Hydroxyamino)Isoindoline-1,3-Dione is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including HPLC, NMR, and MS data, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.