Description

2-Oxaspiro[4.5]Dec-8-Ene-1,7-Dione, 4,6-Dihydroxy-10-Methyl-3-Methylene-, (4R,5R,6S,10R)-Rel-(-)- (9Ci) is a complex, stereochemically defined spirocyclic compound that serves as a high-value synthetic intermediate and building block in advanced organic synthesis. Its intricate molecular architecture, featuring multiple functional groups including diol and dione moieties, makes it a critical precursor for the development of novel pharmaceuticals and fine chemicals. This compound is primarily sought after by research institutions and pharmaceutical R&D departments engaged in medicinal chemistry, process development, and the synthesis of biologically active natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Natural Product Synthesis: Serves as a core scaffold or advanced intermediate in the total synthesis of biologically active natural products.
• Process Chemistry Development: Employed in route scouting and scale-up studies for efficient manufacturing processes.
• Asymmetric Synthesis: Utilized as a chiral template or reagent in stereoselective chemical transformations.
• Fine Chemical Production: Acts as a precursor for specialty chemicals used in agrochemicals and high-performance materials.

Basic Information

Product Name	2-Oxaspiro[4.5]Dec-8-Ene-1,7-Dione, 4,6-Dihydroxy-10-Methyl-3-Methylene-, (4R,5R,6S,10R)-Rel-(-)- (9Ci)
CAS No.	496926-09-1
Molecular Formula	C11H12O5
Molecular Weight	224.21 g/mol
Synonyms	rel-(-)-4,6-Dihydroxy-10-methyl-3-methylene-2-oxaspiro[4.5]dec-8-ene-1,7-dione; (4R,5R,6S,10R)-4,6-Dihydroxy-10-methyl-3-methylene-2-oxaspiro[4.5]dec-8-ene-1,7-dione; 2-Oxaspiro[4.5]dec-8-ene-1,7-dione, 4,6-dihydroxy-10-methyl-3-methylene-, (4R,5R,6S,10R)-rel-(-)-; Spirocyclic Dihydroxy Dione Derivative; CAS 496926-09-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all relevant specifications are provided and available upon request. We support cGMP-compliant manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.