Description

2-Oxaspiro[4.5]Dec-8-Ene-1,7-Dione, 4,6-Dihydroxy-10-Methyl-3-Methylene-, (4R,5R,6R,10R)-Rel-(-)- (9Ci) is a high-purity, stereochemically defined spirocyclic compound with significant synthetic utility. This advanced chemical intermediate is valued for its complex molecular architecture, which serves as a versatile building block for the synthesis of more complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry, process development, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and synthesis of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its complex, functionalized spirocyclic core.
• Asymmetric Synthesis: Serves as a sophisticated starting material or intermediate in stereoselective synthesis routes.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, fragrances, and other high-value compounds requiring precise stereochemistry.
• Academic & Industrial R&D: A valuable compound for methodological development in organic synthesis and catalysis research.
• Process Chemistry: Used in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial production.

Basic Information

Item	Detail
Product Name	2-Oxaspiro[4.5]Dec-8-Ene-1,7-Dione, 4,6-Dihydroxy-10-Methyl-3-Methylene-, (4R,5R,6R,10R)-Rel-(-)- (9Ci)
CAS No.	496926-08-0
Molecular Formula	C11H12O5
Molecular Weight	224.21 g/mol
Synonyms	rel-(-)-4,6-Dihydroxy-10-methyl-3-methylene-2-oxaspiro[4.5]dec-8-ene-1,7-dione; (4R,5R,6R,10R)-4,6-Dihydroxy-10-methyl-3-methylidene-2-oxaspiro[4.5]dec-8-ene-1,7-dione; 2-Oxaspiro[4.5]dec-8-ene-1,7-dione, 4,6-dihydroxy-10-methyl-3-methylene-, (4R,5R,6R,10R)-rel-(-)-; Spirocyclic lactone derivative; Advanced chiral synthon.
EINECS	Contact for details

Quality Control

Our production of 2-Oxaspiro[4.5]Dec-8-Ene-1,7-Dione, 4,6-Dihydroxy-10-Methyl-3-Methylene-, (4R,5R,6R,10R)-Rel-(-)- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure consistent identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing specifications such as assay, enantiomeric excess, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.