Description

2-Amino-6,6-dimethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine-3-carboxylic acid (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused pyranopyridine structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates, particularly in therapeutic areas requiring complex heterocyclic scaffolds.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and the development of new synthetic methodologies.
• Library Synthesis: A valuable component for creating diverse chemical libraries used in high-throughput screening (HTS) for drug discovery.

Basic Information

Product Name	2-Amino-6,6-dimethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine-3-carboxylic acid (Saltdata: Free)
CAS No.	494776-07-7
Molecular Formula	C11H14N2O3
Molecular Weight	222.24 g/mol
Synonyms	6,6-Dimethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine-3-carboxylic acid, 2-amino-; 2-Amino-6,6-dimethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine-3-carboxylic acid; 494776-07-7; 2-Amino-6,6-dimethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine-3-carboxylic acid free base; Pyrano[3,4-b]pyridine-3-carboxylic acid, 2-amino-5,8-dihydro-6,6-dimethyl-6H-; CAS 494776-07-7
EINECS	Contact for details

Quality Control

Our 2-Amino-6,6-dimethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine-3-carboxylic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring suitability for use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.