Description

2-(4-Acetylpiperazino)-5-Bromopyridine is a high-purity, advanced pharmaceutical intermediate featuring a bromopyridine core linked to an acetylpiperazine moiety. This compound is valued for its role as a versatile building block in medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily required by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and protein-protein interactions.
• Process Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.

Basic Information

Product Name	2-(4-Acetylpiperazino)-5-Bromopyridine
CAS No.	494771-76-5
Molecular Formula	C11H14BrN3O
Molecular Weight	284.16 g/mol
Synonyms	5-Bromo-2-(4-acetylpiperazin-1-yl)pyridine; 1-[4-(5-Bromopyridin-2-yl)piperazin-1-yl]ethanone; 2-(4-Acetyl-1-piperazinyl)-5-bromopyridine; 5-Bromo-2-(1-piperazinyl)pyridine, 1-acetyl-; 5-Bromo-2-(4-acetylpiperazino)pyridine; 494771-76-5 (CAS); 2-(N-Acetylpiperazino)-5-bromopyridine
EINECS	Contact for details

Quality Control

Our 2-(4-Acetylpiperazino)-5-Bromopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.