Description

5-Bromo-2-(2,2-difluoroethoxy)pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and fluorinated ether side chain. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides where the difluoroethoxy moiety can influence bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design of molecular probes for studying biological pathways and target engagement.
• Fluorinated Building Block: Provides a source of fluorine atoms, which are highly desirable in modern drug design to modulate potency, selectivity, and ADMET properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects requiring this specific molecular scaffold.

Basic Information

Product Name	5-Bromo-2-(2,2-difluoroethoxy)pyridine
CAS No.	494771-64-1
Molecular Formula	C7H6BrF2NO
Molecular Weight	238.03 g/mol
Synonyms	2-(2,2-Difluoroethoxy)-5-bromopyridine; 5-Bromo-2-(2,2-difluoroethoxy)pyridine; Pyridine, 5-bromo-2-(2,2-difluoroethoxy)-; 494771-64-1; 5-Bromo-2-(2,2-difluoroethoxy)pyridine CAS 494771-64-1
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-(2,2-difluoroethoxy)pyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.