Description

5,8-Methano-9H-Indeno[2,1-C]Pyridin-9-One,4B,5,6,7,8,8A-Hexahydro-,(4Br,5S,8R,8As)-Rel-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters as a critical building block in the synthesis of complex, biologically active molecules, offering precise structural control for demanding research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring sophisticated chiral chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential drug candidates during clinical trial material preparation.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and heterocyclic chemistry.
• Fine Chemical Production: Acts as a precursor for the manufacture of other specialized, high-value chemical entities.

Basic Information

Product Name	5,8-Methano-9H-Indeno[2,1-C]Pyridin-9-One,4B,5,6,7,8,8A-Hexahydro-,(4Br,5S,8R,8As)-Rel-(9Ci)
CAS No.	490039-81-1
Molecular Formula	C15H15BrO
Molecular Weight	291.18 g/mol
Synonyms	(4bR,5S,8R,8aS)-4b,5,6,7,8,8a-Hexahydro-5,8-methanoindeno[2,1-c]pyridin-9-one; rel-(4bR,5S,8R,8aS)-4b,5,6,7,8,8a-Hexahydro-5,8-methano-9H-indeno[2,1-c]pyridin-9-one; 4b,5,6,7,8,8a-Hexahydro-5,8-methanoindeno[2,1-c]pyridin-9-one, (4bR,5S,8R,8aS)-rel-; 5,8-Methano-9H-indeno[2,1-c]pyridin-9-one, 4b,5,6,7,8,8a-hexahydro-, (4bR,5S,8R,8aS)-rel-; Advanced Indenopyridinone Intermediate; Chiral Methanoindeno Pyridinone Derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity assessment by HPLC, to ensure high chemical and isomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development needs with custom synthesis and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; containers should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.