Description

4-Iodophenyl 2,3,4-Tri-o-Acetyl--D-Glucuronide Methyl Ester is a key synthetic intermediate and reference standard in advanced organic and medicinal chemistry. This compound is valued for its role as a protected glucuronide derivative, essential for metabolic and conjugation studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) research, analytical method development, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Reference Standard: Used as a high-purity standard for the quantification and identification of drug metabolites in bioanalytical assays (HPLC, LC-MS).
• Metabolic Pathway Research: Serves as a crucial intermediate in studying Phase II metabolism, specifically glucuronidation pathways of drug candidates.
• Organic Synthesis Building Block: Employed in the synthesis of more complex glucuronidated compounds for biological evaluation and probe development.
• Enzymology Studies: Acts as a substrate or inhibitor in assays for UDP-glucuronosyltransferase (UGT) enzyme activity and characterization.
• Analytical Method Development: Critical for developing and validating sensitive chromatographic methods for metabolite detection in preclinical and clinical samples.

Basic Information

Product Name	4-Iodophenyl 2,3,4-Tri-o-Acetyl--D-Glucuronide Methyl Ester
CAS No.	490028-18-7
Molecular Formula	C19H21IO11
Molecular Weight	552.27 g/mol
Synonyms	Methyl (2,3,4-tri-O-acetyl-1-O-(4-iodophenyl)-α-D-glucopyranosid)uronate; 4-Iodophenyl 2,3,4-Tri-O-acetyl-α-D-glucopyranosiduronic Acid Methyl Ester; 4-Iodophenyl Triacetylglucuronide Methyl Ester; p-Iodophenyl 2,3,4-Tri-O-acetyl-α-D-glucuronide Methyl Ester; 4-Iodophenyl 2,3,4-Tri-O-acetyl-α-D-glucuronide Methyl Ester; 1-O-(4-Iodophenyl)-2,3,4-tri-O-acetyl-α-D-glucopyranuronic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 4-Iodophenyl 2,3,4-Tri-o-Acetyl--D-Glucuronide Methyl Ester is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for the production of reference standards and critical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.