Description

Carbamic Acid, [(1S)-1-(Hydroxymethyl)-2-Methylenebutyl]-, 1,1-Dimethylethyl Ester is a specialized chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex, biologically active molecules, offering a protected amine and alcohol functionality for selective derivatization. Pharmaceutical research and development organizations, particularly those focused on asymmetric synthesis and medicinal chemistry, are the primary users of this high-value intermediate.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in oncology and neurology.
• Asymmetric Synthesis: Used in the stereoselective construction of complex molecular architectures, leveraging its defined (S)-configuration.
• Peptidomimetic Research: Serves as a constrained amino acid analog for designing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) and hydroxymethyl groups provide orthogonal protection points for multi-step synthetic sequences.
• Medicinal Chemistry Libraries: Employed in the parallel synthesis of compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Potential intermediate in the development of chiral, high-performance crop protection agents.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-(Hydroxymethyl)-2-Methylenebutyl]-, 1,1-Dimethylethyl Ester
CAS No.	488727-78-2
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(2S)-4-Methylene-1-[(2-methylpropan-2-yl)oxycarbonylamino]pentan-2-ol; (S)-2-(Hydroxymethyl)-3-buten-1-yl carbamic acid tert-butyl ester; tert-Butyl N-[(1S)-1-(hydroxymethyl)-2-methylenebutyl]carbamate; Boc-L-homoallylglycinol; (S)-2-(Boc-amino)-4-penten-1-ol; Chiral Boc-Protected Amino Alcohol; (1S)-1-(Hydroxymethyl)-2-methylenebutylcarbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Identity, purity, and chiral integrity are verified using advanced analytical techniques including HPLC, GC, and chiral chromatography. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.