Description

2-(N,n-Dimethylaminosulfonyl)Phenylboronic Acid Pinacol Ester is a sophisticated organoboron building block featuring a dimethylaminosulfonyl substituent. This compound is valued for its dual functionality, serving as a protected boronic acid for Suzuki-Miyaura cross-coupling reactions while also offering a handle for further synthetic manipulation via the sulfonamide group. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex aromatic and heteroaromatic scaffolds in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex biaryl structures.
• Suzuki-Miyaura Cross-Coupling: Used as a stable, air- and moisture-tolerant boronic ester reagent for palladium-catalyzed carbon-carbon bond formation.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or precursor for creating functional organic materials, such as organic semiconductors or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors due to its reactive boronate and modifiable sulfonamide groups.
• Process Chemistry & Scale-up: Provides a reliable and consistent starting material for optimizing and scaling synthetic routes in pilot plants.

Basic Information

Item	Details
Product Name	2-(N,n-Dimethylaminosulfonyl)Phenylboronic Acid Pinacol Ester
CAS No.	486422-06-4
Molecular Formula	C15H24BNO4S
Molecular Weight	325.23 g/mol
Synonyms	2-(Dimethylsulfamoyl)phenylboronic acid pinacol ester; [2-(Dimethylsulfamoyl)phenyl]boronic acid pinacol ester; 2-(N,N-Dimethylsulfamoyl)benzeneboronic acid pinacol ester; Pinacol 2-(N,N-dimethylsulfamoyl)phenylboronate; 2-(Dimethylaminosulfonyl)phenylboronic acid pinacol ester; B-[2-(Dimethylsulfamoyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(N,n-Dimethylaminosulfonyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full batch traceability are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.