Description

1-(5-Bromopyridin-2-Yl)Cyclobutanecarbonitrile is a versatile and high-value brominated pyridine derivative, serving as a critical building block in modern synthetic organic chemistry. Its unique structure, featuring both a bromopyridine moiety and a cyclobutane-carbonitrile group, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Advanced Material Development: A building block for organic electronic materials and liquid crystals due to its rigid, conjugated framework.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	1-(5-Bromopyridin-2-Yl)Cyclobutanecarbonitrile
CAS No.	485828-81-7
Molecular Formula	C10H9BrN2
Molecular Weight	237.10 g/mol
Synonyms	1-(5-Bromopyridin-2-yl)cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-(5-bromo-2-pyridinyl)-; 1-(5-Bromo-2-pyridyl)cyclobutanecarbonitrile; 2-(1-Cyanocyclobutyl)-5-bromopyridine; 5-Bromo-2-(1-cyanocyclobutyl)pyridine; 485828-81-7; 1-(5-Bromopyridin-2-yl)cyclobutanenitrile
EINECS	Contact for details

Quality Control

Our production of 1-(5-Bromopyridin-2-Yl)Cyclobutanecarbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.