Description

2-Pyridinecarboxylic Acid, 6-Ethynyl-1,2,3,6-Tetrahydro-, (2S,6R)- (9Ci) is a high-purity, chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for the development of novel pharmaceuticals and bioactive molecules, particularly in the field of neuroscience and enzyme inhibition. Pharmaceutical R&D laboratories and fine chemical manufacturers need this specific stereoisomer to ensure the precise biological activity and efficacy of their target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of central nervous system (CNS) active drugs and enzyme inhibitors.
• Organic Synthesis Building Block: Used in cross-coupling reactions (e.g., Sonogashira) and click chemistry due to the presence of the ethynyl group, enabling the construction of complex molecular architectures.
• Ligand Synthesis: Serves as a precursor for creating novel chiral ligands used in asymmetric catalysis.
• Agrochemical Research: Employed in the discovery of new active ingredients with specific stereochemical requirements.
• Academic & Contract Research: Utilized in university and CRO settings for methodological studies and the synthesis of novel chemical entities for biological screening.

Basic Information

Product Name	2-Pyridinecarboxylic Acid, 6-Ethynyl-1,2,3,6-Tetrahydro-, (2S,6R)- (9Ci)
CAS No.	484664-50-8
Molecular Formula	C9H9NO2
Molecular Weight	163.18 g/mol
Synonyms	(2S,6R)-6-Ethynyl-1,2,3,6-tetrahydropyridine-2-carboxylic acid; (2S,6R)-6-Ethynyl-3,4,5,6-tetrahydro-2H-pyridine-2-carboxylic acid; 6-Ethynyl-1,2,3,6-tetrahydro-2-pyridinecarboxylic acid, (2S,6R)-; (2S,6R)-6-Ethynyl-3,4-dihydro-2H-pyridine-2-carboxylic acid; 484664-50-8; (2S,6R)-6-Ethynyl-2-piperidinecarboxylic acid (tautomeric form).
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarboxylic Acid, 6-Ethynyl-1,2,3,6-Tetrahydro-, (2S,6R)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.