Description

Cyclopropanecarboxamide, 2-(3-Pyridinyl)-, (1R,2S)-Rel- (9Ci) is a high-purity, stereochemically defined chiral compound primarily utilized as a sophisticated building block in advanced pharmaceutical research and development. This compound matters because it provides a critical, structurally unique scaffold for the synthesis of novel active pharmaceutical ingredients (APIs), enabling the exploration of new therapeutic mechanisms. It is specifically needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries working on central nervous system (CNS) agents, kinase inhibitors, and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly in early-stage discovery and lead optimization.
• Medicinal Chemistry Research: Used to introduce the cyclopropane and pyridine pharmacophores into molecular libraries for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Biochemical Tool Compound: May be utilized in vitro to study enzyme inhibition or receptor binding due to its specific stereochemistry and functional groups.
• Asymmetric Synthesis: Employed in chiral pool synthesis or as a template for constructing complex molecules with defined stereocenters.

Basic Information

Product Name	Cyclopropanecarboxamide, 2-(3-Pyridinyl)-, (1R,2S)-Rel- (9Ci)
CAS No.	484654-42-4
Molecular Formula	C9H10N2O
Molecular Weight	162.19 g/mol
Synonyms	(1R,2S)-2-(Pyridin-3-yl)cyclopropanecarboxamide; rel-(1R,2S)-2-(3-Pyridinyl)cyclopropanecarboxamide; (1R,2S)-2-(3-Pyridyl)cyclopropanecarboxamide; 2-(3-Pyridinyl)cyclopropanecarboxamide, (1R,2S)-rel-; 484654-42-4; (1R,2S)-rel-2-(Pyridin-3-yl)cyclopropane-1-carboxamide
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxamide, 2-(3-Pyridinyl)-, (1R,2S)-Rel- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation (NMR, MS). Certificates of Analysis (COA) detailing all specifications are available upon request for every batch shipped.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.