Description

4-(Chloromethyl)-2-(4-Fluorophenyl)Pyridine is a versatile and high-value pharmaceutical intermediate with a distinct pyridine core structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides due to its bioactive pyridine moiety.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of complex molecules for material science.
• Academic & R&D: Employed in university and corporate research laboratories for medicinal chemistry and process development studies.
• API Manufacturing: Integrated into the production scale-up of active pharmaceutical ingredients requiring the 2-(4-fluorophenyl)pyridine scaffold.

Basic Information

Product Name	4-(Chloromethyl)-2-(4-Fluorophenyl)Pyridine
CAS No.	482376-13-6
Molecular Formula	C12H9ClFN
Molecular Weight	221.66 g/mol
Synonyms	2-(4-Fluorophenyl)-4-(chloromethyl)pyridine; 4-(Chloromethyl)-2-(4-fluorophenyl)pyridine; 2-(p-Fluorophenyl)-4-(chloromethyl)pyridine; 4-Fluorophenyl-2-pyridinylmethyl chloride; (4-Fluoro-phenyl)-[4-(chloromethyl)-pyridin-2-yl] (and other structural variations)
EINECS	Contact for details

Quality Control

Our production of 4-(Chloromethyl)-2-(4-Fluorophenyl)Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized using advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.