Description

Eu-DOTA-4Amc is a high-purity, functionalized macrocyclic chelator complex specifically designed for advanced research and diagnostic applications. This compound is critical for creating stable, luminescent probes due to the unique photophysical properties of the europium ion. It is primarily utilized by researchers and manufacturers in the fields of in vitro diagnostics (IVD), bioimaging, and pharmaceutical development who require precise and reliable labeling agents.

Application

• Time-Resolved Fluorescence (TRF) Assays: Serves as a superior luminescent label for immunoassays, enhancing sensitivity and reducing background interference.
• Molecular Imaging Probes: Used in the development of targeted imaging agents for cellular and small animal imaging studies.
• Bioconjugation & Protein Labeling: The reactive 4-aminomethylcyclohexanecarboxylic acid (4Amc) arm facilitates covalent attachment to antibodies, peptides, and other biomolecules.
• Diagnostic Kit Manufacturing: A key component in the production of high-performance clinical diagnostic test kits, including ELISA and lateral flow assays.
• Photophysical Research: Employed in academic and industrial research to study lanthanide luminescence and energy transfer processes.
• Radiopharmaceutical Precursor: The DOTA chelator framework allows for potential adaptation with radiometals for therapeutic or PET imaging applications.

Basic Information

Product Name	Eu-DOTA-4Amc
CAS No.	481668-57-9
Molecular Formula	C26H38EuN5O10
Molecular Weight	~724.55 g/mol
Synonyms	Europium(III) DOTA-4Amc complex; Europium-DOTA-4-aminomethylcyclohexanecarboxylic acid; Eu(III)-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-4Amc; DOTA-Eu-4Amc; TRF-Eu Chelate-4Amc; Eu-DOTA-4-Aminomethylcyclohexanecarboxylate; Luminescent Europium Chelate
EINECS	Contact for details

Quality Control

Our Eu-DOTA-4Amc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity, consistent luminescence yield, and precise chelation stability. Certificates of Analysis (COA) detailing purity, identity, and performance specifications are provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Eu Content (ICP-MS)	18.0 - 21.0 %
Free Europium	≤ 1.0 %
Water Content (KF)	≤ 5.0 %
Luminescence Quantum Yield	Reported value per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.