Description

3-Hydroxy-Cyclobutanecarboxylic Acid Benzyl Ester is a versatile chiral building block and protected intermediate of significant interest in advanced organic synthesis. Its value lies in the functionalized cyclobutane core, which is a key structural motif for modulating the physicochemical properties and biological activity of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon for the development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the strained cyclobutane ring can enhance metabolic stability and efficacy.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry in complex reactions.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique thermal and mechanical properties derived from the four-membered ring structure.
• Flavor and Fragrance Chemistry: Utilized as an intermediate for creating complex aroma chemicals and specialty esters with specific olfactory profiles.
• Academic and Process Chemistry: A valuable reagent for methodological studies in ring-opening and functionalization reactions of strained carbocycles.

Basic Information

Product Name	3-Hydroxy-Cyclobutanecarboxylic Acid Benzyl Ester
CAS No.	480449-99-8
Molecular Formula	C12H14O3
Molecular Weight	206.24 g/mol
Synonyms	Benzyl 3-Hydroxycyclobutanecarboxylate; 3-Hydroxycyclobutanecarboxylic Acid Phenylmethyl Ester; 3-Hydroxy-1-cyclobutanecarboxylic Acid Benzyl Ester; (3-Hydroxycyclobutyl)carboxylic Acid Benzyl Ester; 3-Hydroxycyclobutane-1-carboxylic Acid Benzyl Ester; Benzyl 3-Hydroxycyclobutane-1-carboxylate; 480449-99-8; 3-Hydroxycyclobutanecarboxylate Benzyl Ester
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-Cyclobutanecarboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure consistency and compliance with customer specifications and industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.