Description

L-Proline, 1-[(2E)-1-Oxo-2-Butenyl]-,Methyl Ester CAS NO 480440-16-2 is a specialized proline derivative, an important chiral building block in organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fine chemical, pharmaceutical, and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptidomimetic programs.
• Peptide Chemistry: Used in the synthesis of modified peptides and peptoids to study structure-activity relationships and enhance metabolic stability.
• Agrochemical Research: Serves as a building block for creating novel, biologically active compounds with potential herbicidal or insecticidal properties.
• Asymmetric Synthesis: Employed as a substrate or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Bioconjugation & Probe Development: Useful for creating labeled compounds or probes for biochemical and diagnostic applications due to its reactive ester moiety.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and bioactive molecules.

Basic Information

Product Name	L-Proline, 1-[(2E)-1-Oxo-2-Butenyl]-,Methyl Ester
CAS No.	480440-16-2
Molecular Formula	C10H15NO4
Molecular Weight	213.23 g/mol
Synonyms	L-Proline, 1-(1-oxo-2-butenyl)-, methyl ester; (2S)-1-[(2E)-1-Oxo-2-buten-1-yl]pyrrolidine-2-carboxylic acid methyl ester; Methyl (2S)-1-[(2E)-1-oxobut-2-en-1-yl]pyrrolidine-2-carboxylate; Methyl L-prolinate derivative; N-Crotonoyl-L-proline methyl ester; Proline crotonyl methyl ester; Chiral N-acyl proline ester
EINECS	Contact for details

Quality Control

Our production of L-Proline, 1-[(2E)-1-Oxo-2-Butenyl]-,Methyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.