Description

T-Butyldimethylsilyl Chloroacetate is a versatile organosilicon reagent, primarily valued for its role as a key building block in sophisticated organic synthesis. Its primary function is to introduce the chloroacetate-protected TBDMS group, enabling selective protection and subsequent functionalization in complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where precise control over molecular structure is critical.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex ester and ether linkages under mild conditions.
• Peptide & Nucleotide Chemistry: Used for the selective protection of hydroxyl groups during the solid-phase synthesis of peptides, oligonucleotides, and their analogs.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent in the development of specialty silicones and advanced polymeric materials with tailored properties.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and plant growth regulators that require specific silicon-containing motifs.
• Chemical Research: A fundamental reagent in academic and industrial R&D labs for methodology development and the synthesis of novel chemical entities.
• Protecting Group Strategy: Facilitates multi-step synthetic sequences by providing a robust yet selectively removable protecting group for carboxylic acids and alcohols.

Basic Information

Product Name	T-Butyldimethylsilyl Chloroacetate
CAS No.	480439-47-2
Molecular Formula	C8H17ClO2Si
Molecular Weight	208.76 g/mol
Synonyms	Chloroacetic Acid tert-Butyldimethylsilyl Ester; TBDMS Chloroacetate; tert-Butyldimethylsilyl Chloroacetate; (tert-Butyldimethylsilyl) Chloroacetate; 2-Chloro-1-[(1,1-dimethylethyl)dimethylsilyl]oxy-ethanone; Chloroacetic Acid TBDMS Ester; TBDMS-O-CO-CH2Cl
EINECS	Contact for details

Quality Control

Our T-Butyldimethylsilyl Chloroacetate is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure a typical purity of ≥97% and conformity to precise specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.