Description

tert-Butyldimethylsilyl Bromoacetate is a versatile organosilicon reagent featuring a bromoacetate moiety protected by a tert-butyldimethylsilyl (TBDMS) group. This compound is a critical building block in advanced organic synthesis, particularly for the efficient introduction of functionalized acetate units under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the alkylation of nucleophiles (e.g., amines, thiols, stabilized carbanions) to introduce functionalized acetic acid derivatives, which are common motifs in active pharmaceutical ingredients (APIs).
• Peptide and Protein Modification: Used to selectively label biomolecules or introduce linker arms for bioconjugation and prodrug strategies.
• Material Science and Polymer Chemistry: Serves as a functional monomer or cross-linking agent for creating novel polymers with specific pendant groups.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands and organocatalysts where a protected carboxylic acid functionality is required.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that incorporate halogenated ester functionalities.
• Chemical Biology Probes: Acts as a precursor for activity-based probes (ABPs) or affinity tags to study enzyme function and protein interactions.

Basic Information

Product Name	tert-Butyldimethylsilyl Bromoacetate
CAS No.	480439-46-1
Molecular Formula	C8H17BrO2Si
Molecular Weight	253.21 g/mol
Synonyms	Bromoacetic acid tert-butyldimethylsilyl ester; TBDMS Bromoacetate; (tert-Butyldimethylsilyl) bromoacetate; 2-Bromoacetic acid tert-butyl(dimethyl)silyl ester; Bromoacetic acid TBDMS ester; tert-Butyl(dimethyl)silyl bromoacetate; Silicon, tert-butyldimethyl-, bromoacetate; 480439-46-1
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl Bromoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.