Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, advanced pharmaceutical intermediate (API) with the CAS number 479552-71-1. This compound is a critical building block in modern medicinal chemistry, valued for its unique heterocyclic structure that enables the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing potent and selective kinase inhibitors, a major class of targeted cancer therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug candidate potency, selectivity, and pharmacokinetic properties.
• Bioconjugation & Probe Synthesis: The bromo and sulfonyl functional groups allow for further chemical modifications, making it useful for creating chemical probes and bioconjugates for biological assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel compounds for clinical trials.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	479552-71-1
Molecular Formula	C14H11BrN2O2S
Molecular Weight	351.22 g/mol
Synonyms	5-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-5-bromo-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1H-pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-; 479552-71-1; 5-Br-1-Ts-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.