Description

Methyl 2,5-Difluoro-4-Iodo-3-Methylbenzoate is a high-purity, multi-functional aromatic ester building block designed for advanced organic synthesis. Its molecular structure, featuring strategically placed fluorine and iodine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the difluoro and iodo groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and advanced polymers, leveraging its halogenated aromatic core for fine-tuning material properties.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects requiring high-purity, specialty fluorinated intermediates.

Basic Information

Product Name	Methyl 2,5-Difluoro-4-Iodo-3-Methylbenzoate
CAS No.	479090-49-8
Molecular Formula	C9H7F2IO2
Molecular Weight	312.06 g/mol
Synonyms	2,5-Difluoro-4-iodo-3-methylbenzoic acid methyl ester; Methyl 2,5-difluoro-4-iodo-3-methylbenzoate; Benzoic acid, 2,5-difluoro-4-iodo-3-methyl-, methyl ester; 3-Methyl-2,5-difluoro-4-iodobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2,5-Difluoro-4-Iodo-3-Methylbenzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.