Description

1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride, 1,3-Dimethyl- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. This compound matters as a key acylating agent and versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) due to its acyl chloride functionality.
• Material Science Precursor: Employed in the synthesis of organic ligands for metal-organic frameworks (MOFs) or functional polymers.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride, 1,3-Dimethyl- (9Ci)
CAS No.	479028-65-4
Molecular Formula	C9H8ClN3O
Molecular Weight	209.63 g/mol
Synonyms	1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride; 1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chloride; 1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride (9CI); 1,3-Dimethylpyrazolo[3,4-b]pyridine-5-carbonyl chloride; 5-(Chlorocarbonyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine; 1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride, 1,3-Dimethyl- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.