Description

2-Azetidinecarboxamide,n-(5-Fluoro-2-Pyridinyl)-,(2S)-(9Ci) is a high-purity chiral azetidine derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in its role as a sophisticated intermediate for developing novel, targeted therapeutic agents, particularly in oncology and central nervous system (CNS) research. This compound is essential for R&D chemists and process development scientists in pharmaceutical and biotechnology companies seeking to advance new drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of small molecule drug candidates, especially protease inhibitors and kinase inhibitors.
• Oncology Research: Used in the development of targeted cancer therapies due to its specific molecular scaffold.
• CNS Drug Discovery: Serves as a building block for compounds targeting neurological disorders.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in chiral pool synthesis to introduce the azetidine moiety with high stereochemical fidelity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	2-Azetidinecarboxamide,n-(5-Fluoro-2-Pyridinyl)-,(2S)-(9Ci)
CAS No.	478913-28-9
Molecular Formula	C9H10FN3O
Molecular Weight	195.20 g/mol
Synonyms	(2S)-N-(5-Fluoropyridin-2-yl)azetidine-2-carboxamide; (S)-N-(5-Fluoropyridin-2-yl)azetidine-2-carboxamide; 2-Azetidinecarboxamide, N-(5-fluoro-2-pyridinyl)-, (2S)-; 478913-28-9; (S)-Azetidine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide; UNII-9V3F8P8S4R; 9CI: 2-Azetidinecarboxamide, N-(5-fluoro-2-pyridinyl)-, (2S)-
EINECS	Contact for details

Quality Control

We supply this advanced intermediate under strict GMP-like controls for research and development use. Every batch is characterized and tested to ensure identity, purity, and chiral integrity, with comprehensive analytical data including HPLC, chiral HPLC, 1H/13C NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.