Description

4-Hydroxyazepane-1-Carboxylic Acid tert-Butyl Ester is a protected amino acid derivative belonging to the azepane class, serving as a crucial chiral building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine and carboxylic acid functionalities, enabling selective deprotection and subsequent functionalization for complex molecule construction. This high-purity intermediate is primarily needed by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel therapeutic compounds.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Incorporated into molecular probes and tool compounds for studying biological pathways and target engagement.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to introduce the azepane scaffold.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds under cGMP.

Basic Information

Product Name	4-Hydroxyazepane-1-Carboxylic Acid tert-Butyl Ester
CAS No.	478832-21-2
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	1-Boc-4-hydroxyazepane; tert-Butyl 4-hydroxyazepane-1-carboxylate; 4-Hydroxyazepane-1-carboxylic acid 1,1-dimethylethyl ester; 4-Hydroxyhexamethyleneimine-1-carboxylic Acid tert-Butyl Ester; 1-N-Boc-4-hydroxyazepane; Azepane-1-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester; 4-Hydroxy-1-azepanecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-Hydroxyazepane-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.