Description

1-(4-Chlorobenzyl)-2-Oxo-6-(Trifluoromethyl)-1,2-Dihydro-3-Pyridinecarbonitrile is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. Its molecular architecture, featuring a chlorobenzyl group, a trifluoromethyl substituent, and a nitrile moiety, makes it a critical synthon for constructing complex molecules with tailored biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors who require precise, high-purity intermediates for synthesizing novel active ingredients. Its utility extends to advanced material science applications where its specific electronic properties are leveraged.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme inhibition and receptor-ligand interactions due to its specific pharmacophore elements.
• Material Science Precursor: Acts as a building block for creating specialty polymers and organic electronic materials that require specific fluorinated aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	1-(4-Chlorobenzyl)-2-Oxo-6-(Trifluoromethyl)-1,2-Dihydro-3-Pyridinecarbonitrile
CAS No.	478260-55-8
Molecular Formula	C14H8ClF3N2O
Molecular Weight	312.68 g/mol
Synonyms	1-[(4-Chlorophenyl)methyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile; 3-Cyano-1-(4-chlorobenzyl)-6-(trifluoromethyl)-2(1H)-pyridinone; 1-(4-Chlorobenzyl)-6-(trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 6-(Trifluoromethyl)-1-(4-chlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile; 1-(p-Chlorobenzyl)-6-trifluoromethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chlorobenzyl)-2-Oxo-6-(Trifluoromethyl)-1,2-Dihydro-3-Pyridinecarbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot is characterized using advanced analytical techniques including HPLC, GC-MS, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.