Description

8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine is a high-value, multi-fluorinated heterocyclic compound that serves as a critical advanced intermediate in modern chemical synthesis. Its unique molecular architecture, featuring both chloro and trifluoromethyl substituents on the fused triazolopyridine core, makes it an indispensable building block for creating novel molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where enhanced bioavailability, metabolic stability, and lipophilicity are desired.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Intermediate: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty chemicals, such as ligands for catalysis or monomers for advanced polymers.
• Chemical Biology Probe Development: Utilized in academic and industrial research to create molecular probes for studying biological systems and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine
CAS No.	478248-92-9
Molecular Formula	C9H3ClF5N3
Molecular Weight	283.58 g/mol
Synonyms	8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 478248-92-9; 8-Chloro-3-difluoromethyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyridine; [1,2,4]Triazolo[4,3-a]pyridine, 8-chloro-3-(difluoromethyl)-6-(trifluoromethyl)-; 8-Chloro-3-difluoromethyl-6-trifluoromethyl-1,2,4-triazolo[4,3-a]pyridine
EINECS	Contact for details

Quality Control

Our production of 8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for full characterization. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.