Description

Methyl 2-([3-Cyano-4-(4-Fluorophenyl)-2-Pyridinyl]Sulfanyl)Benzenecarboxylate is a high-value, non-steroidal anti-inflammatory drug (NSAID) intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of advanced pharmaceutical agents, particularly those targeting cyclooxygenase-2 (COX-2) inhibition. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation analgesic and anti-inflammatory medications.

Application

• Key Intermediate in NSAID Synthesis: Serves as a crucial building block in the multi-step synthesis of selective COX-2 inhibitor drugs, such as Celecoxib analogs.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel anti-inflammatory compounds.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of finished dosage forms for targeted pain and inflammation management.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in the production of complex, patent-protected pharmaceutical intermediates.
• Academic Research: Utilized in university and institutional labs for biochemical studies related to inflammation pathways and drug mechanisms.

Basic Information

Product Name	Methyl 2-([3-Cyano-4-(4-Fluorophenyl)-2-Pyridinyl]Sulfanyl)Benzenecarboxylate
CAS No.	478245-93-1
Molecular Formula	C20H13FN2O2S
Molecular Weight	364.40 g/mol
Synonyms	Methyl 2-((3-Cyano-4-(4-fluorophenyl)pyridin-2-yl)thio)benzoate; 2-[(3-Cyano-4-(4-fluorophenyl)-2-pyridinyl)sulfanyl]-Benzoic Acid Methyl Ester; Celecoxib Intermediate; COX-2 Inhibitor Intermediate; 4-[4-(Fluorophenyl)-3-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole; A known precursor in Celecoxib synthesis.
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Every lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and stringent control of residual solvents and impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.